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KMID : 0384320000210030376
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Korean Journal of Family Medicine
2000 Volume.21 No. 3 p.376 ~ p.381
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Profile of serum lipoprotein in patients with subclinical hypothyroidism
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Lee Wou-Weon
Kim Chung-Hwan
Cheong Yoo-Seock
Yoo Sun-Mi
Park Eal-Whan
Park Seok-Gun
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Abstract
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Background : Overt hypothyroidism is a well-known cause of secondary hyperlipidemia and artherosclerosis. However, there have been some dissenting report of abnormalities and in serum lipid concentration in patients with subclinical hypothyroidism. We have attempted to analyze serum lipid concentrations to investigate whether they are increased in patients with subclinical hypothyroidism and to see if there is a correlation between serum LDL-C and TSH concentrations.
Methods : Serum lipid profiles(total cholesterol, triglycerides, LDL-C, HDL-C) of patients with subclinical hypothyroidism (M/F=7/119) compared with age, sex and body mass index matched control subjects(M/F=14/239) from Jan. 1. 1996. to Dec. 30. 1997.
Results : There were no significant differences of serum total cholesterol, LDL cholesterol, TG, and HDL concentrations in 126 patients with subclinical hypothyroidism and 253 control subjects(178.47±35.76㎎/dL vs 173.05±35.93㎎/dL ; 113.33±52.89㎎/dL vs 117.64±68.70㎎/dL ; 112.89±33.26㎎/dL vs 109.65±29.02㎎/dL ; 48.60±11.34㎎/dL vs
46.51±11.73㎎/dL). There was no correlation between LDL cholesterol and TSH concentrations in subclinical hypothyroidism(r=0.29, p〈0.05).
Conclusion : Serum lipid concentration (total cholesterol LDL cholesterol, and TG,HDL) was not increased in patients with subclinical hypothyroidism. There was no correlation between serum LDL and TSH levels in patients with subclinical hypothyroidism.
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KEYWORD
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subclinical hypothyroidism@ serum lipid profile(total cholesterol, triglycerides, low density lipoprotein, high density lipoprotein)
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